This is a graph of the change in ACh release over 13 fifteen minute increments. For the first four collections, artificial cerebrospinal fluid is pumped through the microdialysis probes, to get data on baseline ACh release. Beginning at the the fourth collection interval, NMDA is infused into the nucleus accumbens, which almost immediately increases cortical ACh release in a dose-dependent fashion.
Intra-NAC administration of NMDA increased ACh release in mPFC in a dose-dependent fashion up to 200%. This suggests glutamate wiithin the nucleus accumbens has the potential to affect attentional processing.