The Guttridge Lab at Ohio State investigates the role of the nuclear factor kappa-B (NF-κB) family of transcription factors in the growth and development of skeletal muscle. Recent lab findings have supported the idea that NF-κB functions as an inhibitor of cellular differentiation and have further elucidated the many mechanisms by which this occurs. Current projects in the lab are investigating the NF-κB signaling in myogenesis, rhabdomyosarcoma, Duchenne muscular dystrophy, and cancer cachexia.

This website details the investigation of the effect of cellular differentiation on the anti-apoptotic properties of skeletal muscle cells.

For more information about the interests of the Guttridge Lab or any other muscle research lab at Ohio State or Nationwide Children's Hospital, please visit OSU-Nationwide Muscle Research Group.

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